ECM News
New article on "Quantification of Stretch-Induced Stimuli Altering the Mechanome of Dermal Fibroblasts" is out
Deformation is a key determinant of skin pathophysiology, as seen in skin growth during pregnancy and tissue expansion and in pathological processes such as excessive scarring in wounds under tension. However, the mechanisms underlying dermal cell response to deformation are poorly understood, especially when skin elongation alters the biophysical cell environment, that is, the dermal mechanome. ...
New article on "Introduction to Endothelial Cell Pathophysiology and Angiogenesis" is out
Endothelial cells, which line the innermost layer of blood and lymphatic vessels, are key regulators of the vascular tone, immune response, inflammation, barrier function and angiogenesis. The proper control of these functions is essential to maintain tissue homeostasis, vascular integrity and the overall physiological function. ...
New article on "Reducing Driveline Infection Risk in Durable Mechanical Circulatory Support Devices with Ultra-flexible Wires for Energy Transfer" is out
Driveline infections (DLIs) pose a burden to heart failure patients supported by durable mechanical circulatory support devices (dMCSs). A major factor to DLI comes from the low mechanical compliance of drivelines, affecting wound healing. New drivelines that mitigate mechanical stress on skin may reduce the risk of DLI. We investigate macroscopic and microscopic effects of wires with low flexural stiffness on the risk of DLI. ...
New article on "High-fidelity Thermomechanical Simulation of Laser Powder Bed Fusion Process: Impact of Constitutive Model Choice" is out
Laser Powder Bed Fusion (LPBF) is a widely adopted metal additive manufacturing technology that enables the fabrication of intricate metal components, yet it faces challenges arising from intrinsic residual stress and distortion development. High-fidelity thermomechanical simulations offer essential insights for predicting and mitigating these effects.
New article on "In Vitro Characterization of Endothelial Damage from Rapid Multiaxial Mechanical Loading" is out
Lining the innermost surfaces of blood vessels, endothelial cells form a monolayer which regulates transport from and to the blood. Under physiological conditions, endothelial cells are exposed to various mechanical stimuli including hydrostatic pressure, wall shear stress, and circumferential stretch due to vessel dilation. In clinical procedures, such as venous graft implantation, mechanical thrombectomy, balloon angioplasty and stenting, acute multiaxial stretching of vessels occurs ...