Deformation is a key determinant of skin pathophysiology, as seen in skin growth during pregnancy and tissue expansion and in pathological processes such as excessive scarring in wounds under tension. However, the mechanisms underlying dermal cell response to deformation are poorly understood, especially when skin elongation alters the biophysical cell environment, that is, the dermal mechanome. ...
Endothelial cells, which line the innermost layer of blood and lymphatic vessels, are key regulators of the vascular tone, immune response, inflammation, barrier function and angiogenesis. The proper control of these functions is essential to maintain tissue homeostasis, vascular integrity and the overall physiological function. ...
Driveline infections (DLIs) pose a burden to heart failure patients supported by durable mechanical circulatory support devices (dMCSs). A major factor to DLI comes from the low mechanical compliance of drivelines, affecting wound healing. New drivelines that mitigate mechanical stress on skin may reduce the risk of DLI. We investigate macroscopic and microscopic effects of wires with low flexural stiffness on the risk of DLI. ...