Recently Completed Projects
Constitutive Modelling of Fibre Networks with Stretch Distributions
Network-like structures of randomly arranged and connected fibres are prevalent in a variety of natural as well as technical materials. To understand, analyse and predict the behaviour ... Read Project Details
Multiscale Mechanics of Skin and Skin-Equivalent Materials
The mechanical properties of the human skin are essential for its primary function as a protective barrier against external insults. These properties derive from the microstructure ... Read Project Details
Role of Cellular Senescence in Endothelial Dysfunction
Cellular senescence is a biological process characterized by irreversible proliferative arrest, resistance to apoptosis, presence of senescence-associated secretory phenotype ... Read Project Details
Response of Senescent Endothelial Monolayers to Multiple Mechanical Stimuli
Blood vessels are lined by endothelial cells (ECs) which constantly interact with the luminal and abluminal extracellular environments [1]. Because of their particular location at the interface ... Read Project Details
Multiphasic Phenomena in Soft Biological Membranes
This research focuses on the multiphasic behaviour of biological membranes ... Read Project Details
In-Vivo Biomechanical Analysis for Skin Diagnosis
The SKINTEGRITY project aims at the development of more efficient diagnoses and therapies of skin diseases and acute and chronic wounds ... Read Project Details
Multiscale modeling of musculo-skeletal tissues from virtually reconstructed 3D detailed FE based models
Muscle and tendon tissues are multi-scale materials with fibre bundles embedded in layers of a collagenous scaffolding network, namely extra-cellular matrix (ECM) ... Read Project Details
Nonlinear Analysis of Helical Structures
Current research seeks to develop fundamental models of helical structures that can be used to understand the basis of their mechanical function in collagen tissues ... Read Project Details
Traction-Force Microscopy Analysis of the Cell-ECM Interaction during Cyclic Mechanical Loading
This project focuses on the mechanical interaction of endothelial cells with their substrate under cyclic loading conditions ... Read Project Details
Mechanical Interactions in Fibrous Networks
Unravel the complex relationship between fibre scale and macroscopic properties with a particular focus on the interaction between fibres by friction, compaction and the formation of cross-links ... Read Project Details
Comparative Biomechanics
The objective is to gain insight in the influence of the microstructure on the macroscopically observed nonlinear behavior as well as on the functionality of these tissues ... Read Project Details
Skin Multiscale Mechanics
This research focuses on the contribution of the skin microstructure to the global characteristics of the tissue ... Read Project Details
Tissue Scaffolds for Intervertebral Disc Repair
Electrospinning is well suited for the manufacturing of tissue engineered scaffolds, due to its capability to create planar polymer fiber networks with widely tunable topology and properties ... Read Project Details
Hyperelastic hybrid membrane for biomimetic blood propulsion
Over 26 million people worldwide are affected by heart failure, 6.5 million in Europe. Currently heart transplantation is the only long term solution for this disease ... Read Project Details
Stent Induced Loading of the Aortic Valve Complex
The aim of this project is to develop a procedure that allows the reconstruction of the force fields acting between implant and surrounding tissue ... Read Project Details
Finite Element Modeling of the Face
Understanding of the mechanics of soft biological tissue allows simulating and predicting the mechanical response of complex tissue structures and organs. This provides new opportunities ... Read Project Details
Microstructural Model of Fetal Membranes
The mechanical response of fetal membranes shows particular features related to their function: very compliant response in uniaxial stress state, large biaxial stiffness, large transversal contraction ... Read Project Details
3D Finite Element Pelvic Floor Modeling
Pelvic floor dysfunctions affect a wide range of women of all age groups, more than 10% of which require surgery. However the mechanisms resulting in such pathologies are still poorly understood ... Read Project Details